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Sunday, April 29, 2012
Tumblr President John Maloney Steps Down, Promises ?Awesome New Stuff?
Tumblr President John Maloney just posted (on his Tumblr, natch) that he's stepping down from a day-to-day operational role at the company. "It?s the right time for me and a good time for Tumblr," Maloney writes. "We?re in great hands with David and the excellent leadership team we?ve built."clintonville battlestar galactica blood and chrome my morning jacket roger goodell psychosis dianna agron million hoodie march
Mel Gibson Jokes About Latest Rant With Jay Leno: I've Got a Bit of a Temper ...
Mel Gibson appeared on The Tonight Show With Jay Leno last night and surprisingly, he willingly brought up his most recent secretly recorded meltdown.
He joked about it repeatedly, no less.
The now-infamous Mel Gibson rant, in which he RAGED at Joe Eszterhas (and was taped in his own home, unwittingly, by Eszterhas' son), was over the top, he conceded. Still, Mel believes his privacy was violated and his actions were "justified." Why?
Mel Gibson on The Tonight Show
Eszterhas' script for The Maccabees was non-existent, then awful, Mel said, proceeding to slam the screenwriter for selling him out hardcore in a nine-page letter released online - before he leaked the audiotape.
"If he put half as much time and effort and creativity and imagination into a screenplay, which he was supposed to write, as he did into that letter, we wouldn't be having this conversation," Gibson said of Joe Eszterhas.
As for the rant itself, Leno asked, "So what were you doing, just swearing at the guy?"
"Yeah, pretty much," Mel deadpanned, before adding self-deprecatingly, "Maybe you don't know this about me, but I've got a little bit of a temper."
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Saturday, April 28, 2012
'Shaun Of The Dead' LEGO Set Is Dead In Dailies!
A sad day for fans of LEGOs and "Shaun of the Dead." The proposed LEGO set based on the Edgar Wright film is not going to happen. I'll wait for you to dry your tears. Also, a visual representation of Samuel L. Jackson characters and an awesome Shel Silverstein-J.R.R. Tolkien mash-up in today's Dailies! » [...]
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Google Drive, Weatherwise, Scalado Album, and More [Android Apps Of The Week]
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Airport Terminal Evacuated After TSA Boneheads Neglect to Screen a Baby [WTFriday]
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Hands-On: Google Drive Arrives In ChromeOS Developer Channel
Ever since Google released its cloud storage service Google Drive earlier this week, there has been some speculation as to what its integration with ChromeOS, Google's cloud-centric operating system, would look like. Today, Google released the first developer version of ChromeOS 20 with support for Google Drive. As expected, Google Drive is now deeply integrated into the ChromeOS file manager, though this is clearly just a first effort and still needs quite a bit of work.brian williams patrice o neal patrice o neal paulina gretzky paulina gretzky wayne gretzky wayne gretzky
Zerglings Have Rushed Your Google Search Results. Kill Them All [Google]
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Believe It Or Not: Justin Bieber Unveils Album Cover!
Pop star tweets standard and deluxe album covers for June 19 release, cryptically telling fans, 'expect the unexpected.'
By Katie Byrne
Justin Bieber on his <i>Believe</i> album cover
Photo: Justin Bieber/ Twitter
Judging by the cover art for Justin Bieber's Believe album, the 18-year-old pop star is well aware of one of his best assets: his boyish good looks. The cover, which Bieber tweeted on Friday evening (April 27), is simply a black-and-white close-up of his face with the word "BELIEVE" stamped in a yellow caution-tape font underneath.
"Here is the #BELIEVEalbumCover standard version," he tweeted, followed by a second tweet that included a sepia-toned version of the same image: "and this is the DELUXE #BELIEVEalbumCover - #52DAYS - excited? expect the unexpected."
After posting the Believe album cover on Friday, Bieber retweeted one fan's over-the-top reaction to the artwork: "That awkward moment when I almost ran over a lady and hit the car in front of me cuz I saw the #BELIEVEAlbumCover lololol," @julieannxoxo wrote.
Bieber just revealed the June 19 Believe release date last week on "The Voice," also bringing along a teaser from his yet-unreleased "Boyfriend" video. Even after revealing that sneak peek, Bieber was spotted shooting new scenes for the highly anticipated video, kissing a mystery brunette (hey, that's not Selena!) on set.
"The concept of this video, I mean, it's not like a steady concept," Bieber told MTV News while shooting the video back in March. "It's not like 'Justin follows this girl to this spot.' No, it's a bunch of amazing scenes: like a fire scene, we have an ice scene.
"It's kind of like bouncing back and forth," he said. "And then there's scenes of me and just a bunch of girl dancers, and just some great shots, great artistic shots, great shots of me smiling. It's fun."
What do you think of the album cover? Let us know in the comments below!
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Brittany Dawn Killgore Case: Blood Found in Murder Suspect's Car
Blood matching that of missing Marine wife Brittany Dawn Killgore has been found in the car of the chief suspect in her murder, according to new reports.
Killgore was found dead near a lake in Riverside County. Staff Sgt. Louis Ray Perez and Jessica Lynn Lopez were arrested and charged with murder.
Killgore was supposed to be going out for the evening with a Marine Corps sergeant and his girlfriend until the night of April 13 took a frightening turn.
"She sent a text to a female friend of hers indicating that she was in distress," San Diego Deputy District Attorney Patrick Espinoza said Thursday in court.
"She was missing from that point on."
The first details about the investigation came out at Perez's arraignment in Vista, Calif., where the prosecutor revealed the aforementioned text message.
More significantly, officials also stated that police found Killgore's blood in Perez's car as well as a weapon. Authorities have not revealed a possible motive.
Perez's attorney told the judge that Lopez, who had been found with self-inflicted cuts in a motel room, left a suicide note admitting to Killgore's murder.
Both Lopez, 25, and Perez, 45, have pleaded not guilty to all charges. Killgore, the estranged wife of another U.S. Marine, was only 22 years old.
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Tuesday, April 24, 2012
Making human textiles: Research team ups the ante with development of blood vessels woven from donor cells
ScienceDaily (Apr. 23, 2012) ? A lot of people were skeptical when two young California-based researchers set out more than a decade ago to create a completely human-derived alternative to the synthetic blood vessels commonly used in dialysis patients. Since then, they've done that and more.
"There were a lot of doubts in the field that you could make a blood vessel, which is something that needs to resist pressure constantly, 24-7, without any synthetic materials in it," explains Nicolas L'Heureux, a co-founder and the chief scientific officer of Cytograft Tissue Engineering Inc. "They didn't think that was possible at all." But they were wrong.
Cytograft, which L'Heureux and Todd McAllister co-founded in 2000, has indeed developed vessels that are "completely biological, completely human and living, which is the Cadillac of treatments ? and it seems to work really well," L'Heureux says.
First the team created blood vessels from patients' own skin cells. Then, in June, the company announced that three dialysis patients had received the world's first lab-grown blood vessels made from skin cells from donors, which eliminates the long lead time needed for making vessels from a patient's own cells. And now Cytograft has developed a new technique for making human textiles that promises to reduce the production cost of these vessels by half.
L'Heureux presented his team's latest findings on April 23, at the annual meeting of the American Association of Anatomists, which is being held in conjunction with the Experimental Biology 2012 meeting in San Diego.
Laying the foundation for a human textile
Cytograft's new approach builds on what already has been proved successful. In 2005, the team began extracting fibroblasts from patients' own skin, cultured those cells into thin sheets, rolled up those sheets, cultured them some more so that they would fuse together, and implanted the lab-grown cylindrical vessels. The vessel-growing process was lengthy, at about seven months, but, because the vessels were derived from the patients' own cells, the implants were easily accepted by the patients' bodies, and they held up to the rigors of dialysis, which requires repeated punctures with large-gauge needles.
Then the researchers created allogeneic vessels -- ones grown from donor cells -- with the hope that they were laying the foundation for an off-the-shelf stockpile of 100 percent human replacement parts.
"By combining these two methods we could make something that is allogeneic, cheaper to produce, and that you could store forever, meaning that the clinician can pull it off the shelves whenever they want," L'Heureux explains. "If it is frozen and allogeneic, that is kind of the homerun."
Those donor-based vessels were implanted into three patients in Poland, and they have performed well with no signs of rejection. That accomplishment was a big one, from a manufacturing standpoint, L'Heureux says, because "it is very, very costly to segregate all the patients' cells at all the steps with all the material and all the media and the culturing zones."
Though using donor cells dramatically reduces costs, putting the price tag of a lab-grown human vessel somewhere between $6,000 to $10,000 (although this will come down with automation and volume), it doesn't cut down the manufacturing time all that much, because the culturing of the cells so that they fuse together takes many months. So the researchers decided it was time to try out an idea they'd been kicking around for some years: human textiles.
Not your grandmother's knitting
Today the Cytograft team is deconstructing the sheets of cultured cells into threads and then using a variety of medical-textile-making techniques to weave together blood vessels. Most medical textiles used today are made of permanent synthetic fibers, such as polyester.
"They weave synthetic threads to create patches, for example, for blood vessels ? and they can make a large blood-vessel replacement conduit that they use for arterial repair. They can use patches for hernia repair," L'Heureux explains. "What we are doing here is using a completely biological, completely human -- and chemically nonprocessed in any way -- fiber from which we can now build all kinds of structures by weaving, knitting, braiding or a combination of techniques."
L'Heureux says that, once the cell sheets are grown, the weaving of these human textiles into a vessel takes only a couple of days, even with the prototype loom currently in use at the Cytograft lab. And the threads of cells, while more delicate than synthetic fibers, are strong.
"It is not like your grandmother with the little knitting pins," L'Heureux says. "It is much faster than that. Basically, the time it takes for making the threads and assembling them in a blood vessel is negligible compared to the time that it took you to make the sheet."
The time is now
L'Heureux notes that, having shown that vessels grown from donor cells are a good, natural alternative to synthetic vessels, it's time to roll out "a treatment that is more streamlined and more cost effective," and this third-generation woven allogeneic blood vessel could be the solution.
"We just came to a point where we had proved a lot of what we could do with our blood vessels and it made sense to find a way to make it faster. And this weaving method that makes the vessel out of the same material that we used in the sheet makes it ready in about a third of the time that it took before," he says.
Additionally, he says, weaving actually produces a more robust vessel than one that has been cultured in a cylindrical shape. "There is no seam, which is a problem when you roll something -- there's always a flap on the inside and a flap on the outside, and you need to be sure that these flaps are really well fused with the rest, and that takes a long time for the cells to do," he says.
The work remains in the early stages, and an animal trial showed promising results. For one thing, the woven vessel has proved to resist puncture, "which is important for dialysis," he says.
Next steps
From the beginning, Cytograft's team has focused primarily on the lab-grown vessels' use in dialysis patients, "because that's where the largest need is," L'Heureux says. But they could be used in a variety of patients. Babies with congenital heart defects, for instance, need replacement vessels that can grow and change. Heart bypass patients today endure the often-painful recovery associated with removing a vessel from one part of the body for implantation elsewhere, and a lab-grown and -woven one could eliminate the need for the first surgery.
Also, human-based replacement vessels are far less susceptible to infection than synthetic ones, L'Heureux emphasizes. "With synthetics, one of the big drawbacks is that they get easily infected. What happens is that the synthetic harbors microbes, and immune cells can't deal with the synthetic. They can't grab it. It's like chasing a dog on an ice rink." Immune cells, meanwhile, can recognize and interact with the lab-grown tissue since it is completely biological.
Despite the doubts about Cytograft's work in the early days, there is a push nowadays for finding natural alternatives to synthetics, in part because of the infection risk, L'Heureux says. "Today, 15 years later, the goal of eliminating synthetic materials from tissue-engineered products has become pretty mainstream."
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The above story is reprinted from materials provided by Federation of American Societies for Experimental Biology (FASEB), via Newswise.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
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Sunday, April 22, 2012
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